EMR3

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Egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
Symbols	EMR3;
External IDs	OMIM: 606101 HomoloGene: 50009 IUPHAR: EMR3 GeneCards: EMR3 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • calcium ion binding Cellular component • membrane • integral to membrane Biological process • signal transduction • neuropeptide signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84658	n/a
Ensembl	ENSG00000131355	n/a
UniProt	Q9BY15	n/a
RefSeq (mRNA)	NM_032571	n/a
RefSeq (protein)	NP_115960	n/a
Location (UCSC)	Chr 19: 14.57 - 14.65 Mb	n/a
PubMed search	[1]	n/a

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein that in humans is encoded by the EMR3 gene.

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.

See also

• EGF module-containing mucin-like hormone receptor

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bjarnadóttir TK, Fredriksson R, Höglund PJ; et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matmati M, Pouwels W, van Bruggen R; et al. (2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". J. Leukoc. Biol. 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.