FZD4

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Frizzled homolog 4 (Drosophila)
Identifiers
Symbols	FZD4; EVR1; FEVR; FZD4S; Fz-4; FzE4; GPCR; MGC34390
External IDs	OMIM: 604579 MGI: 108520 HomoloGene: 7325 IUPHAR: FZD4 GeneCards: FZD4 Gene
Gene Ontology Molecular function • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • protein binding • Wnt receptor activity Cellular component • membrane • integral to membrane Biological process • G-protein coupled receptor protein signaling pathway • Wnt receptor signaling pathway • multicellular organismal development Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8322	14366
Ensembl	ENSG00000174804	ENSMUSG00000049791
UniProt	Q9ULV1	Q3V1B2
RefSeq (mRNA)	NM_012193	NM_008055
RefSeq (protein)	NP_036325	NP_032081
Location (UCSC)	Chr 11: 86.33 - 86.34 Mb	Chr 7: 89.28 - 89.29 Mb
PubMed search	[1]	[2]

Frizzled-4 is a protein that in humans is encoded by the FZD4 gene. FZD4 has also been designated as CD344 (cluster of differentiation 344).

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ]
• GeneReview/NIH/UW entry on Familial Exudative Vitreoretinopathy, Autosomal Dominant

Further reading

• Li Y, Fuhrmann C, Schwinger E; et al. (1992). "The gene for autosomal dominant familial exudative vitreoretinopathy (Criswick-Schepens) on the long arm of chromosome 11". Am. J. Ophthalmol. 113 (6): 712–3. PMID 1598965. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Akiyoshi T, Mori M; et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479 Freely accessible. PMID 9707618. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sagara N, Kirikoshi H, Terasaki H; et al. (2001). "FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway". Biochem. Biophys. Res. Commun. 282 (3): 750–6. doi:10.1006/bbrc.2001.4634. PMID 11401527. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1-3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. 
• Robitaille J, MacDonald ML, Kaykas A; et al. (2002). "Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy". Nat. Genet. 32 (2): 326–30. doi:10.1038/ng957. PMID 12172548. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen W, ten Berge D, Brown J; et al. (2003). "Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4". Science. 301 (5638): 1391–4. doi:10.1126/science.1082808. PMID 12958364. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toomes C, Downey LM, Bottomley HM; et al. (2004). "Identification of a fourth locus (EVR4) for familial exudative vitreoretinopathy (FEVR)". Mol. Vis. 10: 37–42. PMID 14737064. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene. 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140. CS1 maint: Multiple names: authors list (link)
• Toomes C, Bottomley HM, Scott S; et al. (2004). "Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy". Invest. Ophthalmol. Vis. Sci. 45 (7): 2083–90. doi:10.1167/iovs.03-1044. PMID 15223780. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshida S, Arita R, Yoshida A; et al. (2004). "Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy". Am. J. Ophthalmol. 138 (4): 670–1. doi:10.1016/j.ajo.2004.05.001. PMID 15488808. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qin M, Hayashi H, Oshima K; et al. (2006). "Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes". Hum. Mutat. 26 (2): 104–12. doi:10.1002/humu.20191. PMID 15981244. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nallathambi J, Shukla D, Rajendran A; et al. (2006). "Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy". Mol. Vis. 12: 1086–92. PMID 17093393. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Planutis K, Planutiene M, Moyer MP; et al. (2007). "Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells". BMC Cell Biol. 8: 12. doi:10.1186/1471-2121-8-12. PMC 1847812 Freely accessible. PMID 17386109. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.