FZD9

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Frizzled homolog 9 (Drosophila)
Identifiers
Symbols	FZD9; FZD3
External IDs	OMIM: 601766 MGI: 1313278 HomoloGene: 2619 IUPHAR: FZD9 GeneCards: FZD9 Gene
Gene Ontology Molecular function • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • Wnt receptor activity Cellular component • plasma membrane • integral to membrane Biological process • G-protein coupled receptor protein signaling pathway • Wnt receptor signaling pathway • multicellular organismal development • nervous system development • learning and/or memory • neuroblast proliferation (sensu Vertebrata) Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8326	14371
Ensembl	ENSG00000188763	ENSMUSG00000049551
UniProt	O00144	Q9R216
RefSeq (mRNA)	NM_003508	XM_284144
RefSeq (protein)	NP_003499	XP_284144
Location (UCSC)	Chr 7: 72.49 - 72.49 Mb	Chr 5: 135.53 - 135.54 Mb
PubMed search	[1]	[2]

Frizzled-9 is a protein that in humans is encoded by the FZD9 gene. FZD9 has also been designated as CD349 (cluster of differentiation 349).

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.

See also

• Frizzled

Further reading

• Datta DV (1977). "Viral hepatitis (Chandigarh study)". The Journal of the Association of Physicians of India. 25 (5): 325–30. PMID 914765. 
• Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233 Freely accessible. PMID 9192640. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Akiyoshi T, Mori M; et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479 Freely accessible. PMID 9707618. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (2002). "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling". J. Biol. Chem. 277 (40): 37479–86. doi:10.1074/jbc.M205658200. PMID 12138115. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winn RA, Marek L, Han SY; et al. (2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". J. Biol. Chem. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winn RA, Van Scoyk M, Hammond M; et al. (2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". J. Biol. Chem. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• "Frizzled Receptors: FZD₉". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• MeSH FZD9+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.