GPR45

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G protein-coupled receptor 45
Identifiers
Symbols	GPR45; PSP24; PSP24(ALPHA); PSP24A
External IDs	OMIM: 604838 MGI: 2135882 HomoloGene: 5228 IUPHAR: GPR45 GeneCards: GPR45 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity Cellular component • integral to plasma membrane • membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • nervous system development Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11250	93690
Ensembl	ENSG00000135973	ENSMUSG00000041907
UniProt	Q9Y5Y3	Q148B5
RefSeq (mRNA)	NM_007227	NM_053107
RefSeq (protein)	NP_009158	NP_444337
Location (UCSC)	Chr 2: 105.22 - 105.23 Mb	Chr 1: 42.9 - 42.98 Mb
PubMed search	[1]	[2]

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.

Further reading

• Kawasawa Y, Kume K, Nakade S; et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)