GPR68

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G protein-coupled receptor 68
Identifiers
Symbols	GPR68; MGC111379; OGR1
External IDs	OMIM: 601404 MGI: 2441763 HomoloGene: 2603 IUPHAR: GPR68 GeneCards: GPR68 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity Cellular component • integral to plasma membrane • membrane Biological process • inflammatory response • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8111	238377
Ensembl	ENSG00000119714	ENSMUSG00000047415
UniProt	Q15743	Q148P7
RefSeq (mRNA)	NM_003485	NM_175493
RefSeq (protein)	NP_003476	NP_780702
Location (UCSC)	Chr 14: 90.77 - 90.79 Mb	Chr 12: 101.28 - 101.29 Mb
PubMed search	[1]	[2]

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.

See also

• Proton-sensing G protein-coupled receptors

Further reading

• Xu Y (2002). "Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction". Biochim. Biophys. Acta. 1582 (1-3): 81–8. PMID 12069813. 
• An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1-2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459. CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. CS1 maint: Multiple names: authors list (link)
• Xu Y, Zhu K, Hong G; et al. (2000). "Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1". Nat. Cell Biol. 2 (5): 261–7. doi:10.1038/35010529. PMID 10806476. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ludwig MG, Vanek M, Guerini D; et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. doi:10.1038/nature01905. PMID 12955148. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bektas M, Barak LS, Jolly PS; et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radu CG, Nijagal A, McLaughlin J; et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMC 545089 Freely accessible. PMID 15665078. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomura H, Wang JQ, Komachi M; et al. (2005). "Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells". J. Biol. Chem. 280 (41): 34458–64. doi:10.1074/jbc.M505287200. PMID 16087674. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Singh LS, Berk M, Oates R; et al. (2007). "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer". J. Natl. Cancer Inst. 99 (17): 1313–27. doi:10.1093/jnci/djm107. PMID 17728215. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)