Leukotriene B4 receptor

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Leukotriene B4 receptor
Identifiers
Symbols	LTB4R; BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
External IDs	OMIM: 601531 MGI: 1309472 HomoloGene: 22477 IUPHAR: BLT1 GeneCards: LTB4R Gene
Gene Ontology Molecular function • nucleotide binding • receptor activity • leukotriene receptor activity Cellular component • integral to plasma membrane • membrane Biological process • cell motility • muscle contraction • inflammatory response • immune response • signal transduction • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	1241	16995
Ensembl	Ensembl:ENSG00000213903	ENSMUSG00000046908
UniProt	Q15722	Q3U2P2
RefSeq (mRNA)	NM_181657	NM_008519
RefSeq (protein)	NP_858043	NP_032545
Location (UCSC)	Chr 14: 24.78 - 24.79 Mb	Chr 14: 54.72 - 54.72 Mb
PubMed search	[1]	[2]

Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.

See also

• Eicosanoid receptor

Further reading

• Raport CJ, Schweickart VL, Chantry D; et al. (1996). "New members of the chemokine receptor gene family". J. Leukoc. Biol. 59 (1): 18–23. PMID 8558062. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2-3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595. 
• Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation". Allergology international : official journal of the Japanese Society of Allergology. 55 (2): 91–7. doi:10.2332/allergolint.55.91. PMID 17075244. CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokomizo T, Izumi T, Chang K; et al. (1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis". Nature. 387 (6633): 620–4. doi:10.1038/42506. PMID 9177352. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704. CS1 maint: Multiple names: authors list (link)
• Gaudreau R, Le Gouill C, Métaoui S; et al. (1998). "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits". Biochem. J. 335 ( Pt 1): 15–8. PMC 1219746 Freely accessible. PMID 9742207. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene". J. Exp. Med. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC 2193224 Freely accessible. PMID 10934229. CS1 maint: Multiple names: authors list (link)
• Yokomizo T, Kato K, Terawaki K; et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMC 2193217 Freely accessible. PMID 10934230. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival". J. Immunol. 168 (7): 3570–6. PMID 11907121. CS1 maint: Multiple names: authors list (link)
• Gaudreau R, Le Gouill C, Venne MH; et al. (2002). "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization". J. Biol. Chem. 277 (35): 31567–76. doi:10.1074/jbc.M202723200. PMID 12077128. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hennig R, Ding XZ, Tong WG; et al. (2002). "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue". Am. J. Pathol. 161 (2): 421–8. PMC 1850753 Freely accessible. PMID 12163367. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito N, Yokomizo T, Sasaki T; et al. (2003). "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release". J. Biol. Chem. 277 (47): 44898–904. doi:10.1074/jbc.M208051200. PMID 12244116. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tong WG, Ding XZ, Hennig R; et al. (2003). "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells". Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor". Adv. Exp. Med. Biol. 507: 357–61. PMID 12664610. CS1 maint: Multiple names: authors list (link)

External links

• "Leukotriene Receptors: BLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• MeSH LTB4R+protein,+human
• MeSH Receptors,+Leukotriene+B4

This article incorporates text from the United States National Library of Medicine, which is in the public domain.