Neuropeptide Y receptor Y5

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Neuropeptide Y receptor Y5
Identifiers
Symbols	NPY5R; NPYR5
External IDs	OMIM: 602001 MGI: 108082 HomoloGene: 21241 IUPHAR: Y5 GeneCards: NPY5R Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • peptide YY receptor activity • pancreatic polypeptide receptor activity • receptor activity Cellular component • integral to plasma membrane • membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • synaptic transmission Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4889	18168
Ensembl	ENSG00000164129	ENSMUSG00000044014
UniProt	Q15761	Q543U8
RefSeq (mRNA)	NM_006174	NM_016708
RefSeq (protein)	NP_006165	NP_057917
Location (UCSC)	Chr 4: 164.48 - 164.49 Mb	Chr 8: 69.61 - 69.62 Mb
PubMed search	[1]	[2]

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.

Selective Ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• BWX-46 (selective NPY₅ agonist, CAS# 172997-92-1)
• Peptide YY

Antagonists

• CGP-71683 (CAS# 192322-50-2)
• FMS-586
• L-152,804 (CAS# 6508-43-6)
• Lu AA-33810
• MK-0557
• NTNCB (CAS# 486453-65-0)

See also

• Neuropeptide Y receptor

External links

• "Neuropeptide Y Receptors: Y₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. CS1 maint: Multiple names: authors list (link)
• Hu Y, Bloomquist BT, Cornfield LJ; et al. (1996). "Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior". J. Biol. Chem. 271 (42): 26315–9. doi:10.1074/jbc.271.42.26315. PMID 8824284. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herzog H, Darby K, Ball H; et al. (1997). "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation". Genomics. 41 (3): 315–9. doi:10.1006/geno.1997.4684. PMID 9169127. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nichol KA, Morey A, Couzens MH; et al. (1999). "Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control". J. Neurosci. 19 (23): 10295–304. PMID 10575027. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodriguez M, Audinot V, Dromaint S; et al. (2003). "Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform". Biochem. J. 369 (Pt 3): 667–73. doi:10.1042/BJ20020739. PMC 1223119 Freely accessible. PMID 12398768. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berglund MM, Schober DA, Statnick MA; et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beauverger P, Rodriguez M, Nicolas JP; et al. (2005). "Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay". Cell. Signal. 17 (4): 489–96. doi:10.1016/j.cellsig.2004.09.006. PMID 15601626. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Movafagh S, Hobson JP, Spiegel S; et al. (2006). "Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors". FASEB J. 20 (11): 1924–6. doi:10.1096/fj.05-4770fje. PMID 16891622. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coletta DK, Schneider J, Stern MP; et al. (2007). "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans". Obesity (Silver Spring, Md.). 15 (4): 809–15. doi:10.1038/oby.2007.610. PMID 17426313. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)