Neurotensin receptor 1
From Self-sufficiency
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| Neurotensin receptor 1 (high affinity) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NTSR1; NTR | ||||||||||||
| External IDs | OMIM: 162651 MGI: 97386 HomoloGene: 68261 IUPHAR: NTS1 GeneCards: NTSR1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4923 | 18216 | |||||||||||
| Ensembl | ENSG00000101188 | ENSMUSG00000027568 | |||||||||||
| UniProt | P30989 | Q9QZQ2 | |||||||||||
| RefSeq (mRNA) | NM_002531 | XM_989244 | |||||||||||
| RefSeq (protein) | NP_002522 | XP_994338 | |||||||||||
| Location (UCSC) | Chr 20: 60.81 - 60.86 Mb | Chr 2: 180.43 - 180.47 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene.[1][2]
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.[2]
See also
References
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<references />, or <references group="..." />External links
- "Neurotensin Receptors: NTS1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- Vincent JP (1996). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cell. Mol. Neurobiol. 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037.
- Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors". Trends Pharmacol. Sci. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
- Vita N, Laurent P, Lefort S; et al. (1993). "Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor". FEBS Lett. 317 (1-2): 139–42. doi:10.1016/0014-5793(93)81509-X. PMID 8381365.
- Le F, Groshan K, Zeng XP, Richelson E (1997). "Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene". J. Biol. Chem. 272 (2): 1315–22. doi:10.1074/jbc.272.2.1315. PMID 8995438.
- Boudin H, Pélaprat D, Rostène W; et al. (1998). "Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra". J. Neurosci. 18 (20): 8473–84. PMID 9763490.
- Ye X, Mehlen P, Rabizadeh S; et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511.
- Wang L, Friess H, Zhu Z; et al. (2000). "Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease". Clin. Cancer Res. 6 (2): 566–71. PMID 10690540.
- Cusack B, Jansen K, McCormick DJ; et al. (2000). "A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist". Biochem. Pharmacol. 60 (6): 793–801. doi:10.1016/S0006-2952(00)00409-3. PMID 10930533.
- Oakley RH, Laporte SA, Holt JA; et al. (2001). "Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*". J. Biol. Chem. 276 (22): 19452–60. doi:10.1074/jbc.M101450200. PMID 11279203.
- Leplatois P, Josse A, Guillemot M; et al. (2001). "Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor". Eur. J. Biochem. 268 (18): 4860–7. doi:10.1046/j.0014-2956.2001.02407.x. PMID 11559354.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Lundquist JT, Büllesbach EE, Golden PL, Dix TA (2002). "Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs". J. Pept. Res. 59 (2): 55–61. PMID 11906607.
- Somaï S, Gompel A, Rostène W, Forgez P (2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochem. Biophys. Res. Commun. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
- Martin S, Navarro V, Vincent JP, Mazella J (2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line". Gastroenterology. 123 (4): 1135–43. doi:10.1053/gast.2002.36000. PMID 12360476.
- Toy-Miou-Leong M, Cortes CL, Beaudet A; et al. (2004). "Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation". J. Biol. Chem. 279 (13): 12636–46. doi:10.1074/jbc.M303384200. PMID 14699144.
- Magazin M, Poszepczynska-Guigné E, Bagot M; et al. (2004). "Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor". J. Invest. Dermatol. 122 (1): 111–8. doi:10.1046/j.0022-202X.2003.22131.x. PMID 14962098.
- Brun P, Mastrotto C, Beggiao E; et al. (2005). "Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G621–9. doi:10.1152/ajpgi.00140.2004. PMID 15764810.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ 2.0 2.1 "Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)".
