Neurotensin receptor 2

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Neurotensin receptor 2
Identifiers
Symbols	NTSR2; NTR2
External IDs	OMIM: 605538 MGI: 108018 HomoloGene: 7452 IUPHAR: NTS2 GeneCards: NTSR2 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • neurotensin receptor activity, G-protein coupled Cellular component • integral to plasma membrane • membrane Biological process • G-protein coupled receptor protein signaling pathway • sensory perception Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23620	18217
Ensembl	ENSG00000169006	ENSMUSG00000020591
UniProt	O95665	Q8VIF4
RefSeq (mRNA)	XM_001129997	NM_008747
RefSeq (protein)	XP_001129997	NP_032773
Location (UCSC)	Chr 2: 11.72 - 11.73 Mb	Chr 12: 16.68 - 16.69 Mb
PubMed search	[1]	[2]

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.

See also

• Neurotensin receptor

External links

• "Neurotensin Receptors: NTS₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors". Trends Pharmacol. Sci. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649. CS1 maint: Multiple names: authors list (link)
• Mazella J, Botto JM, Guillemare E; et al. (1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". J. Neurosci. 16 (18): 5613–20. PMID 8795617. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramez M, Bagot M, Nikolova M; et al. (2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". J. Invest. Dermatol. 117 (3): 687–93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin S, Vincent JP, Mazella J (2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". J. Cell. Sci. 115 (Pt 1): 165–73. PMID 11801734. CS1 maint: Multiple names: authors list (link)
• Bourcier T, Rondeau N, Paquet S; et al. (2002). "Expression of neurotensin receptors in human corneal keratocytes". Invest. Ophthalmol. Vis. Sci. 43 (6): 1765–71. PMID 12036977. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leyton J, Garcia-Marin L, Jensen RT, Moody TW (2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". Eur. J. Pharmacol. 442 (3): 179–86. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070. CS1 maint: Multiple names: authors list (link)
• Somaï S, Gompel A, Rostène W, Forgez P (2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochem. Biophys. Res. Commun. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holst B, Holliday ND, Bach A; et al. (2005). "Common structural basis for constitutive activity of the ghrelin receptor family". J. Biol. Chem. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.