S1PR1

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sphingosine-1-phosphate receptor 1
Identifiers
SymbolsS1PR1; S1P1; EDG1; ECGF1; CHEDG1; D1S3362; EDG-1
External IDsOMIM: 601974 MGI: 1096355 HomoloGene: 1071 IUPHAR: S1P1 GeneCards: S1PR1 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez190113609
EnsemblENSG00000170989ENSMUSG00000045092
UniProtP21453Q3UUK3
RefSeq (mRNA)NM_001400XM_986946
RefSeq (protein)NP_001391XP_992040
Location (UCSC)Chr 1:
101.48 - 101.48 Mb		Chr 3:
115.7 - 115.71 Mb
PubMed search[1][2]

S1PR1 (sphingosine-1-phosphate receptor 1) also known as S1P1 or EDG1 (endothelial differentiation gene 1) is a protein that in humans is encoded by the S1PR1 gene. S1P1 is a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

Function

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.[1]

See also

Interactions

S1PR1 has been shown to interact with 5-HT1A receptor,[2] GNAI1[3] and GNAI3.[3]

References

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Further reading

  • Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441. 
  • Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 476–9. PMID 11915345. 
  • Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348. 
  • Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities". J. Biochem. 131 (6): 767–71. PMID 12038970. 
  • Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". J. Biol. Chem. 265 (16): 9308–13. PMID 2160972. 
  • Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • An S, Bleu T, Huang W; et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733. 
  • Lee MJ, Van Brocklyn JR, Thangada S; et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–5. doi:10.1126/science.279.5356.1552. PMID 9488656. 
  • Lee MJ, Thangada S, Liu CH; et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist". J. Biol. Chem. 273 (34): 22105–12. doi:10.1074/jbc.273.34.22105. PMID 9705355. 
  • Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399. 
  • Windh RT, Lee MJ, Hla T; et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065. 
  • Lee MJ, Thangada S, Claffey KP; et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146. 
  • Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction". J. Biol. Chem. 275 (41): 32363–70. doi:10.1074/jbc.M003075200. PMID 10921915. 
  • Parrill AL, Wang D, Bautista DL; et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate". J. Biol. Chem. 275 (50): 39379–84. doi:10.1074/jbc.M007680200. PMID 10982820. 
  • Liu Y, Wada R, Yamashita T; et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation". J. Clin. Invest. 106 (8): 951–61. doi:10.1172/JCI10905. PMID 11032855. 
  • Murphy WJ, Eizirik E, Johnson WE; et al. (2001). "Molecular phylogenetics and the origins of placental mammals". Nature. 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319. 
  • Hobson JP, Rosenfeldt HM, Barak LS; et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility". Science. 291 (5509): 1800–3. doi:10.1126/science.1057559. PMID 11230698. 
  • Lee MJ, Thangada S, Paik JH; et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis". Mol. Cell. 8 (3): 693–704. doi:10.1016/S1097-2765(01)00324-0. PMID 11583630. 

External links

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  1. ↑ "Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1". 
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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