Difference between revisions of "Neuropeptide Y receptor"
m (Citations: [Pu162]Tweaked: doi. You can use this bot yourself! Report bugs here.) |
(No difference)
|
Latest revision as of 19:01, 10 June 2010
neuropeptide Y receptor Y1 | |
---|---|
Identifiers | |
Symbol | NPY1R |
Alt. symbols | NPYR |
Entrez | 4886 |
HUGO | 7956 |
OMIM | 162641 |
RefSeq | NM_000909 |
UniProt | P25929 |
Other data | |
Locus | Chr. 4 q31.3-q32 |
neuropeptide Y receptor Y2 | |
---|---|
Identifiers | |
Symbol | NPY2R |
Entrez | 4887 |
HUGO | 7957 |
OMIM | 162642 |
RefSeq | NM_000910 |
UniProt | P49146 |
Other data | |
Locus | Chr. 4 q31 |
pancreatic polypeptide receptor 1 | |
---|---|
Identifiers | |
Symbol | PPYR1 |
Alt. symbols | NPY4R, Y4, PP1 |
Entrez | 5540 |
HUGO | 9329 |
OMIM | 601790 |
RefSeq | NM_005972 |
UniProt | P50391 |
Other data | |
Locus | Chr. 10 q11.2 |
neuropeptide Y receptor Y5 | |
---|---|
Identifiers | |
Symbol | NPY5R |
Entrez | 4889 |
HUGO | 7958 |
OMIM | 602001 |
RefSeq | NM_006174 |
UniProt | Q15761 |
Other data | |
Locus | Chr. 4 q31-q32 |
Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.[1] These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.[2][3][4][5][6][7]
Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.
Types
There are five known mammalian neuropeptide Y receptors designated Y1 through Y5.[8] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.[9][10][11]
References
Cite error: Invalid <references>
tag;
parameter "group" is allowed only.
<references />
, or <references group="..." />
External links
- "Neuropeptide Y Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH Neuropeptide+Y+Receptor
40x30px | This transmembrane receptor-related article is a stub. You can help ssf by expanding it. |
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Eaton K, Sallee FR, Sah R (2007). "Relevance of neuropeptide Y (NPY) in psychiatry". Current Topics in Medicinal Chemistry. 7 (17): 1645–59. doi:10.2174/156802607782341037. PMID 17979774.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Vona-Davis LC, McFadden DW (2007). "NPY family of hormones: clinical relevance and potential use in gastrointestinal disease". Current Topics in Medicinal Chemistry. 7 (17): 1710–20. doi:10.2174/156802607782340966. PMID 17979780.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Larhammar D, Salaneck E (2004). "Molecular evolution of NPY receptor subtypes". Neuropeptides. 38 (4): 141–51. doi:10.1016/j.npep.2004.06.002. PMID 15337367.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry. 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781.
- ↑ Kamiji MM, Inui A (2007). "NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs?". Current Topics in Medicinal Chemistry. 7 (17): 1734–42. doi:10.2174/156802607782340957. PMID 17979782.