LGR5

Leucine-rich repeat-containing G protein-coupled receptor 5
Identifiers
Symbols	LGR5; FEX; GPR49; GPR67; GRP49; HG38; MGC117008
External IDs	OMIM: 606667 MGI: 1341817 HomoloGene: 20807 IUPHAR: LGR5 GeneCards: LGR5 Gene
Gene Ontology
Molecular function	• receptor activity; • protein binding; • protein-hormone receptor activity;
Cellular component	• integral to plasma membrane; • membrane; • integral to membrane;
Biological process	• signal transduction; • G-protein coupled receptor protein signaling pathway;
	Sources: Amigo / EGO
RNA expression pattern
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	More reference expression data
Orthologs

Leucine-rich repeat-containing G-protein coupled receptor 5 is a protein that in humans is encoded by the LGR5 gene.^[1]^[2]

LGR5 was recently shown to be present in mouse hair follicles and can potentially be used to regrow hair in mice.

References

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Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
Hsu SY, Kudo M, Chen T; et al. (2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol. Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
Yamamoto Y, Sakamoto M, Fujii G; et al. (2003). "Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations". Hepatology. 37 (3): 528–33. doi:10.1053/jhep.2003.50029. PMID 12601349.
McClanahan T, Koseoglu S, Smith K; et al. (2007). "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors". Cancer Biol. Ther. 5 (4): 419–26. PMID 16575208.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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↑ "Entrez Gene: LGR5 leucine-rich repeat-containing G protein-coupled receptor 5".