Corticotropin releasing hormone receptor 1

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Corticotropin releasing hormone receptor 1
Identifiers
Symbols	CRHR1; CRF-R; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f
External IDs	OMIM: 122561 MGI: 88498 HomoloGene: 20920 IUPHAR: CRF1 GeneCards: CRHR1 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • corticotrophin-releasing factor receptor activity Cellular component • plasma membrane • integral to plasma membrane • membrane Biological process • response to stress • immune response • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, coupled to cAMP nucleotide second messenger • adenylate cyclase activation • female pregnancy • parturition • behavior Sources: Amigo / EGO
RNA expression pattern
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More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1394	12921
Ensembl	ENSG00000120088	ENSMUSG00000018634
UniProt	P34998	Q0VGH2
RefSeq (mRNA)	XM_001128344	NM_007762
RefSeq (protein)	XP_001128344	NP_031788
Location (UCSC)	Chr 17: 41.24 - 41.27 Mb	Chr 11: 103.95 - 103.99 Mb
PubMed search	[1]	[2]

Corticotropin releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF₁, with the latter (CRF₁) now being the IUPHAR-recommended name. In humans, CRF₁ is encoded by the CRHR1 gene.

Function

The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.

CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.

Clinical significance

Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma. CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.

Interactions

Corticotropin releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone and Urocortin.

See also

• Corticotropin releasing hormone
• Corticotropin releasing hormone receptor
• Corticotropin releasing hormone antagonists
• Antalarmin
• Pexacerfont

External links

• "Corticotropin-releasing Factor Receptors: CRF₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

• MeSH CRF+receptor+type+1

Further reading

• Taché Y, Martinez V, Wang L, Million M (2004). "CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome". Br. J. Pharmacol. 141 (8): 1321–30. doi:10.1038/sj.bjp.0705760. PMC 1574904 Freely accessible. PMID 15100165. CS1 maint: Multiple names: authors list (link)
• McLean M, Bisits A, Davies J; et al. (1995). "A placental clock controlling the length of human pregnancy". Nat. Med. 1 (5): 460–3. doi:10.1038/nm0595-460. PMID 7585095. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Polymeropoulos MH, Torres R, Yanovski JA; et al. (1995). "The human corticotropin-releasing factor receptor (CRHR) gene maps to chromosome 17q12-q22". Genomics. 28 (1): 123–4. doi:10.1006/geno.1995.1118. PMID 7590738. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen R, Lewis KA, Perrin MH, Vale WW (1993). "Expression cloning of a human corticotropin-releasing-factor receptor". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8967–71. doi:10.1073/pnas.90.19.8967. PMC 47482 Freely accessible. PMID 7692441. CS1 maint: Multiple names: authors list (link)
• Ross PC, Kostas CM, Ramabhadran TV (1995). "A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology". Biochem. Biophys. Res. Commun. 205 (3): 1836–42. doi:10.1006/bbrc.1994.2884. PMID 7811272. CS1 maint: Multiple names: authors list (link)
• Opdenakker G, Fiten P, Nys G; et al. (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics. 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vita N, Laurent P, Lefort S; et al. (1993). "Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors". FEBS Lett. 335 (1): 1–5. doi:10.1016/0014-5793(93)80427-V. PMID 8243652. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Donaldson CJ, Sutton SW, Perrin MH; et al. (1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liaw CW, Grigoriadis DE, Lovenberg TW; et al. (1997). "Localization of ligand-binding domains of human corticotropin-releasing factor receptor: a chimeric receptor approach". Mol. Endocrinol. 11 (7): 980–5. doi:10.1210/me.11.7.980. PMID 9178757. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asakura H, Zwain IH, Yen SS (1997). "Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary". J. Clin. Endocrinol. Metab. 82 (8): 2720–5. doi:10.1210/jc.82.8.2720. PMID 9253360. CS1 maint: Multiple names: authors list (link)
• Gottowik J, Goetschy V, Henriot S; et al. (1998). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology. 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grammatopoulos D, Dai Y, Chen J; et al. (1998). "Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria". J. Clin. Endocrinol. Metab. 83 (7): 2539–44. doi:10.1210/jc.83.7.2539. PMID 9661640. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakai K, Yamada M, Horiba N; et al. (1998). "The genomic organization of the human corticotropin-releasing factor type-1 receptor". Gene. 219 (1-2): 125–30. doi:10.1016/S0378-1119(98)00322-9. PMID 9757017. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grammatopoulos DK, Dai Y, Randeva HS; et al. (2000). "A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes". Mol. Endocrinol. 13 (12): 2189–202. doi:10.1210/me.13.12.2189. PMID 10598591. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lewis K, Li C, Perrin MH; et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709 Freely accessible. PMID 11416224. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perrin MH, Fischer WH, Kunitake KS; et al. (2001). "Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor". J. Biol. Chem. 276 (34): 31528–34. doi:10.1074/jbc.M101838200. PMID 11425856. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pisarchik A, Slominski AT (2002). "Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression". FASEB J. 15 (14): 2754–6. doi:10.1096/fj.01-0487fje. PMID 11606483. 
• Graziani G, Tentori L, Portarena I; et al. (2002). "CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway". Endocrinology. 143 (3): 807–13. doi:10.1210/en.143.3.807. PMID 11861501. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• King JS, Bishop GA (2003). "The distribution and cellular localization of CRF-R1 in the vermis of the postnatal mouse cerebellum". Exp. Neurol. 178 (2): 175–85. doi:10.1006/exnr.2002.8052. PMID 12504877. 

External links

• IUPHAR GPCR Database - Corticotropin-releasing factor receptors
• MeSH Corticotropin-releasing+hormone+receptors

This article incorporates text from the United States National Library of Medicine, which is in the public domain.