Indeloxazine

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Indeloxazine
File:Indeloxazine.svg
Systematic (IUPAC) name
2-(3H-inden-4-yloxymethyl)morpholine
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Biological half-life 2.2 hours
Identifiers
CAS Number 60929-23-9
ATC code none
PubChem CID 3704
Chemical data
Formula C14H17NO2
Molar mass 231.290 g/mol[[Script error: No such module "String".]]
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Indeloxazine (Elen, Noin) is a so-called cerebral activator used in Japan for the treatment of cerebrovascular disease.[1] It was launched in 1988.[2] Indeloxazine acts as a serotonin releasing agent and norepinephrine reuptake inhibitor.[3] It also acts as an NMDA receptor antagonist.[4] It enhances acetylcholine release through indirect activation of the 5-HT4 receptor.[5][6][7] Indeloxazine has nootropic,[8][9][6][7] neuroprotective,[10][11][12][13] anticonvulsant,[14] and antidepressant effects.[15][16][3]

See also

References

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Acetylcholinesterases
Ampakines
CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • IDRA-21 • LY-404,187 • LY-503,430 • PEPA • Sunifiram • Unifiram
D1 Agonists
Eugeroics
GABAA α5 Inverse Agonists
H3 Antagonists
mACh Agonists
nACh Agonists
Racetams
Others
GABAA receptor agonist
Other GABA agents
Carbonic anhydrase inhibitor
Channel blockers
Primarily sodium
Primarily calcium
Unknown/ungrouped
Indirect GABA agents
Unknown/multiple/
unsorted
GABAA PAMs
Others
α2δ VDCC Blockers
5-HT1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane
H1 Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine
CRH1 Antagonists
NK2 Antagonists
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
Others

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc, drug(N5A/5B/5C/6A/6B/6D)


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  1. ↑ "Index nominum, international drug ... - Google Books". 
  2. ↑ "Dictionary of pharmacological agents - Google Books". 
  3. ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  5. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  6. ↑ 6.0 6.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  7. ↑ 7.0 7.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  8. ↑ Ogawa N, Haba K, Sora YH, Higashida A, Sato H, Ogawa S (1988). "Comparison of the effects of bifemelane hydrochloride and indeloxazine hydrochloride on scopolamine hydrobromide-induced impairment in radial maze performance". Clinical Therapeutics. 10 (6): 704–11. PMID 3219685. 
  9. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  10. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  11. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  12. ↑ Shimizu-Sasamata M, Terai M, Harada M, Yamamoto M (1993). "Anti-hypoxic and anti-ischemic actions of indeloxazine hydrochloride and its optical isomers: possible involvement of cerebral energy metabolism". Archives Internationales De Pharmacodynamie Et De Thérapie. 324: 33–46. PMID 8297184. 
  13. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  14. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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  16. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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