Flupentixol

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Flupentixol
File:E-Z-Isomers of Flupentixol.png
Systematic (IUPAC) name
(EZ)-2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol
Clinical data
Routes of
administration
Oral, IM
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Biological half-life 19-39 hours
Identifiers
CAS Number 2709-56-0
ATC code N05AF01 (WHO)
PubChem CID 5281881
DrugBank APRD00388
ChemSpider 4445173
Chemical data
Formula C23H25F3N2OS
Molar mass 434.5219 g/mol
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Flupentixol (INN), also known as flupenthixol (former BAN), marketed under brand names such as Depixol and Fluanxol, is a typical antipsychotic drug of the thioxanthene class.

Indications

Flupentixol's main use is as a long-acting injection given two or three times weekly to individuals with schizophrenia who have poor compliance with medication and suffer frequent relapses of illness. In some countries it can be administered involuntarily under outpatient commitment laws.

Flupentixol is also used in low doses as an antidepressant.[1][2][3][4][5][6]

Pharmacology

Flupentixol acts as an antagonist at various dopamine (D1-D5), serotonin (5-HT2), adrenaline (α1), and histamine (H1) receptors,[7] without affecting the muscarinic acetylcholine receptors.[8]

Its antipsychotic effects are likely caused by D2 and/or 5-HT2A antagonism, whereas its antidepressant effects at lower doses may be mediated by preferential D2/D3 autoreceptor blockade, resulting in increased postsynaptic activation.

Side effects

The side effects of flupentixol are similar to most other typical antipsychotics, namely extrapyramidal symptoms of akathisia, muscle tremors, and rigidity and antihistamine effects like sedation and somnolence. However, it lacks anticholinergic adverse effects.

See also

References

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  2. Pöldinger W, Sieberns S (1983). "Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate". Neuropsychobiology. 10 (2-3): 131–6. PMID 6674820. 
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  7. "PDSP Database - UNC". 
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