Dopamine receptor D5
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| Dopamine receptor D5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | DRD5; DBDR; DRD1B; DRD1L2; MGC10601 | ||||||||||||
| External IDs | OMIM: 126453 MGI: 94927 HomoloGene: 20216 IUPHAR: D5 GeneCards: DRD5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1816 | 13492 | |||||||||||
| Ensembl | ENSG00000169676 | ENSMUSG00000039358 | |||||||||||
| UniProt | P21918 | Q8BLD9 | |||||||||||
| RefSeq (mRNA) | NM_000798 | NM_013503 | |||||||||||
| RefSeq (protein) | NP_000789 | NP_038531 | |||||||||||
| Location (UCSC) | Chr 4: 9.39 - 9.39 Mb | Chr 5: 38.61 - 38.61 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
D(1B) dopamine receptor is a protein that in humans is encoded by the DRD5 gene.[1][2][1]
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase.[3] This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosome 1 and chromosome 2.[2]
Contents
Ligands
The D1 and D5 receptors have a high degree of structural homology and few ligands are available that can distinguish between them as yet, however there are a number of ligands that are selective for D1/5 over the other dopamine receptors. The recent development of a selective D5 antagonist has allowed the action of D1-mediated responses to be studied in the absence of a D5 component, but no selective D5 agonists are yet available.
Agonists
No selective ligands known as of yet.
Antagonists
- 4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol: antagonist, moderate binding selectivity over D1[4]
File:4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz-d,g-azecin-3-ol.png
Chemical structure of a D5-preferring ligand 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol.[4]
Interactions
Dopamine receptor D5 has been shown to interact with GABRG2.[5]
See also
References
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<references />, or <references group="..." />Further reading
- Missale C, Nash SR, Robinson SW; et al. (1998). "Dopamine receptors: from structure to function". Physiol. Rev. 78 (1): 189–225. PMID 9457173.
- Grandy DK, Allen LJ, Zhang Y; et al. (1992). "Chromosomal localization of three human D5 dopamine receptor genes". Genomics. 13 (4): 968–73. doi:10.1016/0888-7543(92)90009-H. PMID 1387108.
- Eubanks JH, Altherr M, Wagner-McPherson C; et al. (1992). "Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus". Genomics. 12 (3): 510–6. doi:10.1016/0888-7543(92)90442-U. PMID 1532789.
- Sunahara RK, Guan HC, O'Dowd BF; et al. (1991). "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1". Nature. 350 (6319): 614–9. doi:10.1038/350614a0. PMID 1826762.
- Tiberi M, Jarvie KR, Silvia C; et al. (1991). "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7491–5. doi:10.1073/pnas.88.17.7491. PMC 52326 Freely accessible. PMID 1831904.
- Grandy DK, Zhang YA, Bouvier C; et al. (1991). "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9175–9. doi:10.1073/pnas.88.20.9175. PMC 52675 Freely accessible. PMID 1833775.
- Weinshank RL, Adham N, Macchi M; et al. (1991). "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene". J. Biol. Chem. 266 (33): 22427–35. PMID 1834671.
- Sobell JL, Lind TJ, Sigurdson DC; et al. (1995). "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease". Hum. Mol. Genet. 4 (4): 507–14. doi:10.1093/hmg/4.4.507. PMID 7633397.
- Beischlag TV, Marchese A, Meador-Woodruff JH; et al. (1995). "The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region". Biochemistry. 34 (17): 5960–70. doi:10.1021/bi00017a025. PMID 7727453.
- Sherrington R, Mankoo B, Attwood J; et al. (1994). "Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1". Genomics. 18 (2): 423–5. doi:10.1006/geno.1993.1489. PMID 8288248.
- Sidhu A, Kimura K, Uh M; et al. (1998). "Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz". J. Neurochem. 70 (6): 2459–67. doi:10.1046/j.1471-4159.1998.70062459.x. PMID 9603210.
- Cargill M, Altshuler D, Ireland J; et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.
- Liu F, Wan Q, Pristupa ZB; et al. (2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 (6767): 274–80. doi:10.1038/35002014. PMID 10659839.
- Misbahuddin A, Placzek MR, Chaudhuri KR; et al. (2004). "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm". Neurology. 58 (1): 124–6. PMID 11781417.
- Kabbani N, Negyessy L, Lin R; et al. (2002). "Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor". J. Neurosci. 22 (19): 8476–86. PMID 12351722.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Hemby SE, Trojanowski JQ, Ginsberg SD (2003). "Neuron-specific age-related decreases in dopamine receptor subtype mRNAs". J. Comp. Neurol. 456 (2): 176–83. doi:10.1002/cne.10525. PMID 12509874.
- Zheng S, Yu P, Zeng C; et al. (2003). "Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron". Hypertension. 41 (3): 604–10. doi:10.1161/01.HYP.0000057422.75590.D7. PMID 12623966.
External links
- "Dopamine Receptors: D1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH DRD5+protein,+human
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ 2.0 2.1 "Entrez Gene: DRD5 dopamine receptor D5".
- ↑ Sidhu A (1998). "Coupling of D1 and D5 dopamine receptors to multiple G proteins: Implications for understanding the diversity in receptor-G protein coupling". Mol. Neurobiol. 16 (2): 125–34. doi:10.1007/BF02740640. PMID 9588624.
- ↑ 4.0 4.1 Mohr P, Decker M, Enzensperger C, Lehmann J (2006). "Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist". J. Med. Chem. 49 (6): 2110–6. doi:10.1021/jm051237e. PMID 16539400.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
