Adhyperforin

Adhyperforin
	File:Adhyperforin.png
Systematic (IUPAC) name
	dicyclohexylammonium; (1R,5S,6R,7S)-6-methyl-5-(2-methylbutanoyl)-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-2,9-dioxo-bicyclo[3.3.1]non-3-en-4-olate
Clinical data
Routes of; administration	Oral
Legal status
Legal status	Over-the-counter;
Identifiers
CAS Number	143183-63-5
ATC code	none
PubChem	CID 44427224
ChemSpider	23287670
Chemical data
Formula	C18H77NO4
Molar mass	732.13 g/mol[[Script error: No such module "String".]]
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Adhyperforin is a phytochemical found in the members of the plant genus Hypericum including St. John's Wort.^[1] It has a very similar pharmacological profile to hyperforin and acts as a TRPC6 ion channel activator,^[1] thereby inhibiting the reuptake of various neurotransmitters including serotonin, norepinephrine, dopamine, GABA, and glutamate.^[1] Adhyperforin is found in St. John's Wort in levels approximately 1/10th those of hyperforin.^[1]

References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 Jensen AG, Hansen SH, Nielsen EO. (2001). "Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity". Life Sci. 68 (14): 1593–1605. doi:10.1016/S0024-3205(01)00946-8. PMID 11263672.